Summary: Researchers trained a deep neural network on magnetic resonance imaging (MRI) scans from nearly 15,000 cognitively healthy adults aged 19 to 100. Moving beyond a single-number “brain age,” the model produces high-resolution 3D maps that estimate local brain age at the voxel level. When applied to people with mild cognitive impairment (MCI) and Alzheimer’s … Read more

Summary: Researchers at Nagoya University have identified neural mechanisms that support sustained effort toward goals, showing that orexin-producing neurons are essential drivers and regulators of motivated behavior. The study combines chemogenetics, fiber photometry, and optogenetics to reveal how orexin neuron activity tracks expected rewards and effort demands. Key Facts Effort-linked activation: Fiber photometry recordings in … Read more

Summary: A recent McGill University study finds that subtle changes in physical posture can influence feelings and decision-making without participants’ awareness. The research shows that sitting more upright leads to slightly better strategic risk-taking and higher self-reported pride compared with slouched or neutral postures. Key Facts Implicit posture manipulation: Instead of instructing participants to adopt … Read more

Summary: Researchers have developed an artificial intelligence foundation model that extracts hidden physiological signals from routine overnight polysomnography to predict long-term health risks, identifying patient groups with markedly different outcomes that standard sleep metrics miss. Key Facts Two-fold mortality risk difference: The AI model stratified patients into five risk groups. Individuals in the highest-risk group … Read more

Summary: A new study shows that as the human brain moves into deep REM sleep, it shifts sensory priority away from external sounds and toward internal cardiac signals. Researchers quantify this shift with a novel “audio-cardio index” that may serve as a physiological indicator of altered consciousness. Key Facts Selective sensory reprioritization: During the transition … Read more

Summary: A neuroscience study shows that melodies people imagine can be decoded and reconstructed from surface electrode brain signals recorded during intracranial monitoring. Researchers recorded invasive brain activity from ten epilepsy patients who were already undergoing clinical intracranial monitoring. Each participant listened to the opening bars of familiar children’s songs, silently imagined how the melody … Read more

Summary: A new study from the University of Toronto finds that when people unexpectedly gain free time, their brains treat that time as subjectively longer than expected. This perceived expansion of time leads to slower behavior, choice of longer activities, and poorer time management—often causing people to miss or be late for later commitments despite … Read more

Summary: New research from The University of Texas MD Anderson Cancer Center reveals a shared neuroimmune mechanism that helps explain how rapid-acting antidepressants—such as ketamine and serotonergic psychedelics—can quickly reduce symptoms in treatment-resistant depression. The study identifies blood-based immune markers, including interleukin-15 (IL-15), interleukin-7 (IL-7) and B-cell signaling pathways, that align with changes in brain … Read more

Summary: A four-year longitudinal study found that regular participation in municipally supported community gathering places lowered the risk of developing cognitive disability by roughly 50% among older adults who did not maintain routine exercise habits. Researchers followed 2,578 community-dwelling older adults in Habikino City, Osaka Prefecture, who were not certified as requiring long-term care at … Read more

Summary: Researchers reveal an unexpected dual role for the telomeric protein TRF2: in addition to protecting chromosome ends, TRF2 actively preserves muscle stem cell identity and supports tissue regeneration. New research from the Perelman School of Medicine at the University of Pennsylvania shows that TRF2 functions beyond telomere protection. In skeletal muscle, TRF2 dynamically controls … Read more