Summary: The Alzheimer’s Tau Platform (ATP) trial is the first large-scale study specifically designed to evaluate combination therapies that target both amyloid plaques and tau tangles at once. Uniquely, ATP screens and treats people who are asymptomatic but show early biological indicators of Alzheimer’s on advanced imaging, with the aim of interrupting the disease process … Read more

Summary: An international team of researchers from more than 20 institutions synthesized decades of clinical and experimental work to explain how many modern, human-made environments overload our visual systems. Combining mathematical analysis of natural scene statistics with neurocomputational models, the review identifies how common urban patterns—repeating geometry, high contrast, flicker, and clutter—drive excessive neural activity … Read more

Summary: Scientists have identified a specific subpopulation of epinephrine-producing neurons, called C1 neurons, that act as powerful drivers of fear and persistent anxiety. Under normal conditions, these cells issue a short-lived alarm during intense stress. The new study shows that prolonged, intense activation of this pathway can lock a downstream stress center into a prolonged … Read more

Summary: Researchers have shown that the human brain processes very low-frequency sound—known as infrasound—through a distinct biological pathway. When acoustic waves fall below the range that ordinary auditory hair cells can transduce, the mechanical energy bypasses those sensory cells and instead activates the cochlea’s structural support cells. These support cells produce alternative electrical potentials that … Read more

Summary: A recent study from the University of Freiburg shows that randomly timed sounds played during sleep can actively impair memory consolidation. Using real-time electroencephalography (EEG), researchers found that brief ambient clicks disturb deep slow-wave sleep, blocking the physical propagation of slow brain waves across the cortex and breaking the information transfer necessary for forming … Read more

Summary: Researchers have released a new suite of clinical resources—a concise practical guide and a short documentary film—designed to improve how professionals, families, and communities respond when people report hearing voices, including voices that relate to suicide. The project shows that, for many, hearing voices can be an adaptive response to overwhelming psychological distress rather … Read more

Summary: Recent evidence shows that astrocytes—long considered passive support cells—play an active, central role in neural circuitry and emotional regulation. Researchers mapped cellular mechanisms that convert healthy astrocytes into neurotoxic phenotypes and identified these glial changes as a core driver of overlapping psychiatric symptoms and instability in brain networks linked to mood disorders. Key Facts … Read more

Summary: Researchers have shown that losing normal TDP-43 function specifically in microglia disrupts brain development. Without TDP-43, microglia experience a collapse of the TREM2–DAP12 signaling pathway and can no longer clear routine myelin errors produced during early wiring. This breakdown of neuro-immune housekeeping damages oligodendrocytes, impairs myelin integrity, and produces lasting motor deficits in adult … Read more

Summary: New research examined the corticostriatal circuit — a key neural pathway that supports decision-making, goal-directed actions, and behavioral flexibility — and found that alcohol interacts with Alzheimer’s-related pathologies in unexpectedly different ways. In animal models that isolate amyloid-beta pathology, alcohol sharply reduced communication across this circuit. In models dominated by tau pathology, the same … Read more

Summary: Researchers report that a ketogenic diet—which shifts the body from glucose toward fat-derived ketones for fuel—produced rapid metabolic benefits and notable improvements in persistent psychiatric symptoms. By bypassing impaired glucose pathways, the intervention restored brain energy availability and produced measurable gains in metabolic health, cognition, and mood without major adverse effects. This randomized controlled … Read more